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|Title||η4-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)|
The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (η4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.
|Published in||Bioorganic & medicinal chemistry letters|
|Series||Volume: 16, Number: 4|
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