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http://hdl.handle.net/20.500.12358/24397
TitleProfiling of human stratum corneum ceramides by means of normal phase LC/APCI–MS
Untitled
Abstract

The ceramides of the stratum corneum are critical to maintaining the epidermal barrier function of the skin. A number of skin diseases and disorders are known to be related to impairments of the ceramide pattern. Therefore, obtaining mass spectrometric profiles of the nine ceramide classes known to exist aids our understanding of the underlying molecular mechanisms, which should eventually lead to new diagnostic opportunities: for example, the mass spectrometric profiles of patients suffering from serious skin diseases such as atopic dermatitis and psoriasis can be compared to those of healthy controls. Previous work on mass spectrometric analysis of ceramides relied mostly on GC/MS after hydrolysis and derivatization. The introduction of ESI–MS and LC/ESI–MS has provided new options for directly analyzing intact ceramides. However, some of the ceramide classes are not accessible to ESI–MS …

Authors
Farwanah, Hany
Wohlrab, Johannes
Neubert, Reinhard HH
Raith, Klaus
TypeJournal Article
Date2005
Published inAnalytical and bioanalytical chemistry
SeriesVolume: 383, Number: 4
PublisherSpringer-Verlag
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  • Staff Publications- Faculty of Medicine [149]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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