Antihyperglycaemic effect of Saliva leriifolia Benth leaf and seed extract in mice.

Mwafy, Saleh N; Yassin, Maged M.; Organization, World Health; George, M; Ayuso, E; Casellas, A; Costa, C; Devedjian, JC; Bosch, F; Setter, SM; Iltz, JL; Thams, J; Campbell, RK; Szkudelski, T; Ashour, Ara; Elyazji, Nehad R.; Krauss, H; Kozlik, J; Gryzymislawski, M; Sosnowski, P; Mikrut, K; Piatek, J; Paluszak, J; West, E; Simon, OR; Morrison, EY; Seifter, S; England, S; Baquer, NZ; El-Agouza, I; Rawy, A; Saad, A; Lashin, A; El-Sisi, S; Gawronska-Szklarz, B; Musial, DH; Pawlik, A; Paprota, B; Bando, K; Yamada, Y; Sato, J; Ohsawa, I; Oshida, Y; Sato, Y; Sakamoto, N; Ali, L; Azad-Khan, AK; Hassan, Z; Mosihuzzaman, M; Nahar, N; Grover, JK; Yadav, S; Vats, V; Haeba, MH; Mohamed, Abdurahman; Mehdi, AW; Nair, GA; Mythili, MD; Vyas, R; Akila, G; Gunasekaran, S; Nieszner, E; Posa, I; Kocsis, E; Pogatsa, G; Preda, I; Koltai, MZ; Adam, Sei; Al-Yahya, MA; Al-Farhan, AH; Travis, JC; Trinder, P; Thomas, L; Bessey, OA; Lowry, OH; Brock, MJ; Bogardus, C; Lillioja, S; Howard, V; Reaven, G; Mott, D; Hebden, RA; Gardiner, SM; Bennet, T; Macdonald, IA; Abu-Amra, E; Defranzo, RA; Simonson, DC; Cheta, DM; Lim, J; Chan, EK; Kunakorn, T; Charles, MA; Ashcroft, Sjh; Ashcroft, FM; Alberti, Kgmm; Zimmet, PZ; Defronzo, RA; Mondal, DK; Yousuf, BM; Banu, LA; Ferdousi, R; Shamim, KM; Yaniv, Z; Dafni, A; Friedman, J; Palevitch, D; Yanardag, R; Ozsoy-Sacan, O; Orak, H; Ozgey, Y; Tanaka, K; Ashour, Abd El Rahiem A.; Ashour, A; Ravi, K; Sivagnanam, K; Subramaniam, S; Hosseinzadeh, H; Khodaparast, Hmh; Shokohizadeh, H

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http://hdl.handle.net/20.500.12358/24378

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Title	Antihyperglycaemic effect of Saliva leriifolia Benth leaf and seed extract in mice.
Abstract	The present study is aimed to assess the therapeutic potential of sulfonylurea drug glimepiride in comparison with Nerium oleander plant extract on insulin, glucose levels and some liver enzymes activities in streptozotocin-induced diabetic rats. Rats were rendered diabetic by intraperitoneal injection of a single dose of 50 mg kg-1 body weight streptozotocin. Rats with serum glucose levels >200 mg dL-1 were subdivided into three sub-groups: the first sub-group were remained without treatment and considered as diabetics. The second and third subgroups were orally administered 0.1 mg kg-1 body weight/day glimepiride and 250 mg kg-1 body weight/day Nerium oleander, respectively for 4 weeks. Streptozotocin-induced diabetic rats showed hypoinsulinemia and hyperglycemia compared to controls. Strong negative correlation (r = -0.8) was found between serum insulin and glucose levels in diabetic rats. This …
Authors	Mwafy, Saleh N Yassin, Maged M. Organization, World Health George, M Ayuso, E Casellas, A Costa, C Devedjian, JC Bosch, F Setter, SM Iltz, JL Thams, J Campbell, RK Szkudelski, T Ashour, Ara Elyazji, Nehad R. Krauss, H Kozlik, J Gryzymislawski, M Sosnowski, P Mikrut, K Piatek, J Paluszak, J West, E Simon, OR Morrison, EY Seifter, S England, S Baquer, NZ El-Agouza, I Rawy, A Saad, A Lashin, A El-Sisi, S Gawronska-Szklarz, B Musial, DH Pawlik, A Paprota, B Bando, K Yamada, Y Sato, J Ohsawa, I Oshida, Y Sato, Y Sakamoto, N Ali, L Azad-Khan, AK Hassan, Z Mosihuzzaman, M Nahar, N Grover, JK Yadav, S Vats, V Haeba, MH Mohamed, Abdurahman Mehdi, AW Nair, GA Mythili, MD Vyas, R Akila, G Gunasekaran, S Nieszner, E Posa, I Kocsis, E Pogatsa, G Preda, I Koltai, MZ Adam, Sei Al-Yahya, MA Al-Farhan, AH Travis, JC Trinder, P Thomas, L Bessey, OA Lowry, OH Brock, MJ Bogardus, C Lillioja, S Howard, V Reaven, G Mott, D Hebden, RA Gardiner, SM Bennet, T Macdonald, IA Abu-Amra, E Defranzo, RA Simonson, DC Cheta, DM Lim, J Chan, EK Kunakorn, T Charles, MA Ashcroft, Sjh Ashcroft, FM Alberti, Kgmm Zimmet, PZ Defronzo, RA Mondal, DK Yousuf, BM Banu, LA Ferdousi, R Shamim, KM Yaniv, Z Dafni, A Friedman, J Palevitch, D Yanardag, R Ozsoy-Sacan, O Orak, H Ozgey, Y Tanaka, K Ashour, Abd El Rahiem A. Ashour, A Ravi, K Sivagnanam, K Subramaniam, S Hosseinzadeh, H Khodaparast, Hmh Shokohizadeh, H
Type	Journal Article
Date	1999
Published in	Pakistan Journal of Biological Sciences
Series	Volume: 14, Number: 21
Publisher	orgz
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Collections	Staff Publications- Faculty of Medicine [149]

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