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http://hdl.handle.net/20.500.12358/24328
TitleActivation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice
Untitled
Abstract

The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 activation in keratinocytes causes sebaceous gland enlargement and seborrhea in mice due to upregulation of the growth factor epigen, which we identified as a novel Nrf2 target. This was accompanied by thickening and hyperkeratosis of hair follicle infundibula. These abnormalities caused dilatation of infundibula, hair loss, and cyst development upon aging. Upregulation of epigen, secretory leukocyte peptidase inhibitor (Slpi), and small proline‐rich protein 2d (Sprr2d) in hair follicles was identified as the likely cause of infundibular acanthosis, hyperkeratosis, and cyst formation. These alterations were highly reminiscent to the phenotype of chloracne/“metabolizing acquired dioxin‐induced skin …

Authors
Schäfer, Matthias
Willrodt, Ann‐helen
Kurinna, Svitlana
Link, Andrea S
Farwanah, Hany
Geusau, Alexandra
Gruber, Florian
Sorg, Olivier
Huebner, Aaron J
Roop, Dennis
Sandhoff, Konrad
Saurat, Jean‐hilaire
Tschachler, Erwin
Schneider, Marlon R
Langbein, Lutz
Bloch, Wilhelm
Beer, Hans‐dietmar
Werner, Sabine
TypeJournal Article
Date2014
Published inEMBO molecular medicine
PublisherEMBO Press
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  • Staff Publications- Faculty of Medicine [149]
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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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The institutional repository of the Islamic University of Gaza was established as part of the ROMOR project that has been co-funded with support from the European Commission under the ERASMUS + European programme. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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