Browsing Staff Publications- Faculty of Medicine by Author "2d79d051-9e20-4426-a6ba-6b218e0ceb02"

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Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes

Ginkel, Christina; Hartmann, Dieter; Dorp, Katharina Vom; Zlomuzica, Armin; Farwanah, Hany; Eckhardt, Matthias; Sandhoff, Roger; Degen, Joachim; Rabionet, Mariona; Dere, Ekrem; Dörmann, Peter; Sandhoff, Konrad; Willecke, Klaus (American Society for Biochemistry and Molecular Biology, 2012)

Background: Ceramide synthase 1 catalyzes the synthesis of C18 ceramide and is mainly expressed in neurons of the brain. Results: Ablation of Ceramide Synthase 1 decreases ganglioside levels and expression of oligodendrocytic ...
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas

Imgrund, Silke; Hartmann, Dieter; Farwanah, Hany; Eckhardt, Matthias; Sandhoff, Roger; Degen, Joachim; Gieselmann, Volkmar; Sandhoff, Konrad; Willecke, Klaus (American Society for Biochemistry and Molecular Biology, 2009)

(Dihydro) ceramide synthase 2 (cers2, formerly called lass2) is the most abundantly expressed member of the ceramide synthase gene family, which includes six isoforms in mice. CERS2 activity has been reported to be specific ...