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Loss of CB1 receptors leads to decreased cathepsin D levels and accelerated lipofuscin accumulation in the hippocampus
Piyanova, Anastasia; Albayram, Onder; Rossi, Carlo Alberto; Farwanah, Hany; Michel, Kerstin; Nicotera, Pierluigi; Sandhoff, Konrad; Bilkei-Gorzo, Andras (Elsevier, 2013)Early onset of age-related changes in the brain of cannabinoid 1 receptor knockout (Cnr1−/−) mice suggests that cannabinoid 1 (CB1) receptor activity significantly influences the progression of brain aging. In the present ...